To troubleshoot why your PowerPoint presentation is not saving the slide layout changes, consider the following steps:

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1. Check your version of PowerPoint. Make sure the version is up to date and compatible with the presentation file.
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2. Check compatibility. Ensure that the presentation is compatible with the version of PowerPoint you’re using.
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3. Check permissions. Ensure that you are the owner of the presentation and that you have proper permission to make changes.
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4. Check for malicious software. Make sure your computer is clear of viruses and malware that could cause your PowerPoint presentation to not save changes.
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5. Check file size. Too many slides may cause the presentation to stop saving changes, so try reducing the number of slides.